QUOTE (Blackshroud @ Sep 28 2009, 11:10 AM)

Well he met Death because Ajax removed his heart when his healing factor wasn't working. Thanos making him immortal out of jealousy came later.
I'm a little late to the game here, but I can't resist. I'm a Deadpool fangirl like woah.
Wade actually met Death before having his heart removed. After flunking out of, well, life - he was trying to kill himself in the Hospice. Another inmate/patient Worm had a popular death pool going on - one that Wade rose to the top of simply because Ajax kept foiling his attempts at suicide... which is how he got the nickname Deadpool, but I digress...
What with being in constant pain because of crazy-cancer-skin, being tortured by Dr. Killbrew, and being pretty freakin' upset over what his life had come to, Wade was 100% ready to die - which was why and when he started seeing Death. She, in turn, was fascinated by him as she'd never met anyone quite so... erm... dead and not-dead at the same time.
Long story short, they got along well which led Wade to more and more suicide attempts in order to see her again. He started making jokes at Ajax's expense, annoying the hell out of the big guy so he would be less tempted to save his life/more inclined to end it. This had the unintentional side-effect of raising morale at the hospice - which pushed Ajax over the edge.
To spite Wade, Ajax had Worm lobotomized. Wade was upset. Death suggested killing Worm out of mercy and he did. Of course, killing another inmate was a big no-no, and Ajax was finally able to convince Killbrew that Wade needed to be put down.
Death was pleased with this. Wade would have been pleased, but he was just too angry at Ajax for what he had done. He wanted revenge so much that, after he was executed, it kick-started his healing factor. Death was not pleased. Wade
definitely wasn't pleased once he realized he couldn't die and, likewise, couldn't see Death anymore.
Later on down the line, he did actually manage to die. But, because Thanos is one jealous SOB, he went ahead and cursed Deadpool with immortality for good measure.
Coincidentally, I made an MV about these two once:
http://www.youtube.com/watch?v=0JFV5UcmqHoIs my nerd showing yet?
On a related note, I'm quite pleased that Way's been incorporating some Death into recent Pool-O-Visions.
Edit: Being nit-picky here, but I'm not sure Death is technically female either. Death is just the personification of death. She/he/it is whatever someone wants she/he/it to be. At least, I think that's the cannon... But, I dunno, Marvel's confusing like that.